What is the suggested protocol for using the take-up indicator?

The take-up indicator (red laser) is, of course, good for initially specific drills in training trigger mechanics. When conducting higher-volume training, such as working on draws, reloads, target transitions, etc., turn the take-up indicator off. If you teach or practice front-sight focus, maintain that front sight focus/awareness and see the shot break with the green laser in your peripheral vision. If you instruct or practice more of a target focus, then train mount your gun, exercise proper trigger control and use the green laser to confirm your quality of movement.

In the course of your training, turning on the take-up indicator is advantageous for certain drills to illustrate muzzle movement during shooting on the move, transitions (to ensure the shooter is slowing down the pistol properly and not over transitioning past the target) and certain other specific drills.